Juice the Melon:
Blend the diced honeydew until smooth, then strain through a fine mesh sieve. Set aside 2 oz of the juice for the cocktail.

Muddle the Jalapeno:
In a shaker, add the jalapeño slices and agave syrup. Muddle gently to release the flavor.

Build and Shake:
Add mezcal, honeydew juice, lime juice, and a pinch of salt to the shaker. Fill the shaker with ice and shake hard for about 15 seconds until well chilled.

Strain and Serve:
Strain into a chilled highball glass over fresh ice. Top with txakoli wine. Add a sprig of mint for garnish. Serve immediately.